None listed
Conditions
Interventions
Intervention1: 1. Epigallocatechin -3- gallete
2. Caffeine
3. Capsaicin
4. Cinnamaldehyde: Dose of dietary bioactive compounds -
1. Epigallocatechin-3- gallate from green tea- 300mg
2. Caffeine fro
Sponsors
St Johns Research Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy Indian male volunteers aged 18-30 years 2. BMI between 18.5-29.9 Kg/m�² 3. Normal renal and liver function tests 4. Subjects willing to give informed consent 5. Subjects being stable weight for last 3 months
Exclusion criteria
Exclusion criteria: 1. Subjects with hypertension, diabetes 2. History of chronic cigarette smoking or any form of addictions 3. Subjects using anorectic or related compounds 4. History of allergic rhinitis, nasal block 5. Subjects on any long term medications especially bronchodilators, thyroxin 6. Subject consuming caffeine >200mg/day (more than 4 cups coffee per day) 7. Subjects consuming alcohol >120ml on regular basis/ consumed within 48 hrs of the study 8. Those who have physical activity level (PAL) > 1.5 for the past 48 hrs 9. Subjects consumed alcohol and caffeine 24 hour prior to the experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of epigallocatechin-3-gallete (EGCG), caffeine, capsaicin and cinnamaldehyde on EE (REE, DIT and SEE) and nocturnal fat oxidation among normal weight and overweight/obese young (18-30 years) healthy Indian males.Timepoint: The nocturnal fat oxidation and energy expenditure will be assessed after supplementing for one day. The outcome will be measured on five nights with a wash out of minimum 3 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To study the intra-individual variability in nocturnal fat oxidation among normal and overweight/obese subjects. 2. To investigate the effect of purified extracts of mentioned bioactive compounds on heart rate variability, blood pressure and body temperature 3. To examine the associations of EE and fat oxidation with body composition, insulin sensitivity, habitual physical activity pattern, sleeping pattern and nutrient intakeTimepoint: 1. Heart rate variability, blood pressure and body temperature - 5 time points in each experiment 2. Body composition, glucose tolerance and insulin sensitivity- 1 time point for each subject 3. Habitual physical activity pattern, sleeping pattern, nutrient intake and habitual consumption of the bioactive compounds- 1 time point for each subject | — |
Countries
India
Contacts
Public ContactMs Srishti Sinha
St Johns Research Institute
Outcome results
None listed