Health Condition 1: null- Renal Transplant
Conditions
Interventions
Intervention1: Azathioprine: TAC (0.15 mg/kg/day in 2 divided doses) will be started on the day prior to renal transplant, targeting a trough level of 8 to 12 ng/ml for the first 3 months, respective
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults of either sex undergoing their first living donor renal transplant 2. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Sensitised patients 2. Pregnant or Nursing mothers 3. Patients suffering from any malignancy requiring immediate surgery, ongoing chemotherapy or radiation, 4. Patients with untreated hypercholesterolemia defined as having total cholesterol >200 mg/dl, triglycerides > 300mg/dL, 5. Patient having significant liver disease defined as having during the past 30 days continuously elevated SGOT and or SGPT levels greater than 3 times the upper value of normal range, patients suffering from severe diarrhoea, vomiting, GI malabsorption or active peptic ulcer disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute RejectionTimepoint: 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Graft loss, estimated glomerular filtration rate and adverse eventsTimepoint: 6 and 12 months | — |
Countries
India
Contacts
Public ContactSarabpreet Singh
PGIMER
Outcome results
None listed