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Comparison of efficacy of two sedative drugs in oral cancer surgery patients

Comparative evaluation of efficacy of intravenous infusion of Dexmedetomidine with Morphine for postoperative analgesia and sedation in head and neck cancer surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/02/011997
Enrollment
50
Registered
2018-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx Health Condition 2: null- Patients scheduled for elective head and neck cancer surgery of age 20-70years of either sex with ASA grade 1-2

Interventions

Intervention1: Dexmedetomidiine: Patients in Group D will receive I.V Bolus: 1µg/kg of dexmedetomidine over 10 min thirty minutes prior to anticipated completion of surgery. I.V Infusion of dexmedeto

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective head and neck cancer surgery of age 20-70 years of both sexes of ASA grade 1-2

Exclusion criteria

Exclusion criteria: Patient refusal, Respiratory insufficiency Haemodynamic instability,Abnormal thyroid function, Renal or hepatic insufficiency, History of any chronic pain,Unstable personality and abuse liability and History of chronic opioid use

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the efficacy of intravenous infusion of dexmedetomidine with morphine as sedative and analgesic agent in mechanically ventilated patients who have undergone head and neck cancer surgeryTimepoint: After shifting to ICU till discharge from ICU—

Secondary

MeasureTime frame
1. Additional requirements of rescue sedatives and analgesics with each drug. 2. Adverse effects like hemodynamic disturbances including hypotension and bradycardia Timepoint: Till discharge from ICU—

Countries

India

Contacts

Public ContactDr Sachidanand Jee Bharati

All India Institute of Medical Sciences

sachidadr@yahoo.co.in29575101

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026