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Effect of addition of Dexamethasone as adjuvant to intrathecal bupivacaine with only Bupivacaine in Spinal analgesia

Dexamethasone as adjuvant to intrathecal bupivacaine in spinal analgesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/02/011994
Enrollment
60
Registered
2018-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing surgery PAC fit Health Condition 2: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: Drug given in Intradural spinal space.: Dexamethasone 8.0 mg (2ml) was added to 3.0 ml of Bupivacaine intrathecally in study group, while 2.0 ml of normal saline in 3.0 ml of Bupivacain

Sponsors

Peoples College of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA gr I-II between the age group of 18 to 65 years for lower limb and lower abdominal surgery willing to participate in study.

Exclusion criteria

Exclusion criteria: Patients not willing to participate, with H/O long term steroid therapy, uncontrolled hypertension,diabetes mellitus, known neurologic disorder, psychological disorder, spinal column surgery, with low backache, chronic alcoholics, opium addition,or any drug which modifies pain were excluded.

Design outcomes

Primary

MeasureTime frame
Sensory block was btn T 6 to T 10 in both groups. no difference observed in both group.Sensory block lasted for 109 min + 10 min in study group, it lasted for 90 + 8.0 min in control group. Indicating significant increase in time of sensory block.Requirement of supplemental analgesic dose was longer in study group than in control group.The hypotension have shown no difference in both the groups. complications bradycardia and nausea and vomiting showed no difference.Timepoint: Sensory level controlled by OT table tilt every 30 seconds for 20 minutes then every 5 minutes till 4 sensory level regression from highest level or surgery completion. Onset calculated as time from inj. of drugs into intrathecal space to peak of highest sensory and motor block and the duration of sensory block calculated from peak of block to 4 sensory level regressions or patient felt pain in the field of surgery. They instructed to inform the earliest feel of pain.

Secondary

MeasureTime frame
The sensory block was between T 6 and T 10. There was no significant difference in both groups in level of sensory block.Timepoint: The sensory block was between T 6 and T 10. Level of block was almost similar in both groups.

Countries

India

Contacts

Public ContactDr Kanhaiya Lal Kishnani

Department of Anesthesia

drkishnani@gmail.com07554004010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026