Health Condition 1: null- HepatoCellular Carcinoma Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Institute of liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age between 18-70 years. 2) Proven cirrhosis (Defined in appendix 1). 3) HCC proven by standard radiological criteria within last 1-month 4) No HCC on dynamic CT and/or dynamic MRI (protocol defined in appendix 1) done within last 1 month
Exclusion criteria
Exclusion criteria: 1) Previous biopsy or FNA of the tumor.1 2) Previous invasive radiological procedures TACE/RFA. 3) Previous or ongoing chemotherapy or biological therapy. 4) Previous liver resection or transplant. 5) Segmental / main PV thrombosis.2 6) Atypical enhancement on imaging 7) Extrahepatic metastatic spread of HCC3 8) Coexisting sepsis. 9) Renal dysfunction, as defined by serum creatinine >1.5mg/dL.5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of circulating tumor cells (CTCs) and amount of cell-free DNA (cfDNA) in cirrhotic patients with hepatocellular carcinoma (HCC) Timepoint: 0 | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of Circulating Tumor Cells in the peripheral blood of cirrhotic patients in both groups Timepoint: 0;Number of Circulatory Tumor Cells and cfDNA amount with the tumor size, tumor number, and Barcelona Clinic of Liver Cancer (BCLC) stage of HepatoCellular CarcinomaTimepoint: 0;To study if addition of CTCs and/or cfDNA estimates to existing diagnostic algorithm improves the discriminating ability for HCC among patients with cirrhosis. Timepoint: 0;To study the difference in amount of cfDNA in the peripheral blood of cirrhotic patients with and without HCC. Timepoint: 0 | — |
Countries
India
Contacts
Public ContactDr Majul Mishra
Institute of liver and Biliary Sciences
Outcome results
None listed