Health Condition 1: null- Children with diabetic ketoacidosis
Conditions
Interventions
Intervention1: Ringerâ??s lactate: Will receive the Ringerâ??s lactate via intravenous route as per fluid charting (usually 85 per kg after deduction of fluid blous if any along with routine maintenan
Sponsors
The Director
Eligibility
Inclusion criteria
Inclusion criteria: Children aged <15-year with diabetic ketoacidosis admitted to pediatric critical care unit. (DKA will be defined as per ISPAD guideline)
Exclusion criteria
Exclusion criteria: 1. Children with diabetic ketoacidosis who have already received intravenous fluid for more than four-hrs. 2. Children with a septic shock (requiring >= 60 ml/kg fluid bolus(s) and vasoactive therapy to maintain vitals parameters during initial resuscitation).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the time taken for resolution of acidosis and frequency of acute kidney injury in children with diabetic ketoacidosis treated with balanced salt solution as compared to those treated with normal saline and Ringerâ??s lactate.Timepoint: During PICU and Hospital discharge (First 7 days usually). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the frequency and course of acute kidney injury including an effect on acute kidney injury biomarker [Neutrophil gelatinase-associated lipocalin (NGAL) in blood and urine.Timepoint: During PICU and Hospital discharge (First 7 days usually).;2. To compare the time taken to reach the blood glucose level â?¤ 250 mg/dl.Timepoint: During PICU and Hospital discharge (First 7 days usually).;3. To compare the frequency of hyperchloremia.Timepoint: During PICU and Hospital discharge. (First 7 days usually));4. To compare the length of pediatric intensive care unit and hospital stay.Timepoint: During PICU and Hospital discharge.(First 7 days usually);5. To compare the frequency of cerebral edema and / or worsening of cerebral edema.Timepoint: During PICU and Hospital discharge.(First 7 days usually);6. To compare the cost involved Cost-effectiveness analysis among the three groups.Timepoint: During PICU and Hospital discharge.(First 7 days usually) | — |
Countries
India
Contacts
Public ContactDR RAMESH KUMAR R
JIPMER
Outcome results
None listed