Health Condition 1: null- Cirrhosis Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Metaclopromide group: Metoclopromide will be given 10mg intravenous thrice daily
Intervention2: Erythromycin group: Erythromycin will be given intravenous 70mg twice daily
Control Inter
Sponsors
Institute of liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients who develop new onset feed intolerance to enteral nutrition
Exclusion criteria
Exclusion criteria: 1) Any patient with current or past surgical abdomen including mechanical obstruction, mesenteric ischemia, perforation or requiring abdominal surgery. 2) Patients receiving enteral nutrition through gastrostomy or jejunostomy. 3)Patients in whom, prokinetics are contraindicated or are allergic to the same. 4)Patients who received prokinetic more than one day prior to the start of enteral feeding. 5)Patients with uncontrolled sepsis with DIC. 6)Requirement of two or more vasopressors. 7)Organ failure requiring high inotropic support. 8)Advanced cardiopulmonary disease, with prior history of arrhythmias, structural heart disease. 9)History of traumatic brain injury, raised intracranial pressure, history of myasthenia gravis. 10)Endocronolgic illnesses: Hypothyroidism, hypoparathyroidism 11)Connective tissue diseases (systemic sclerosis, dermatomyositis or polymyositis, systemic lupus erythematosis, amyloidosis). 12)Known case of diabetes with diabetic gastroparesis 13)Pregnancy 14)Patients or concerned family member who fail to give consent for study enrollment 15)Age less than 18 years and more than 70 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of feed intolerance at 24 hours with improvement in 3 or more points and initiation of entral feeding.Timepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with Initiation of entral nutrition more than 50%. of recommended nutrition (Kcal/kg body weight/day).Timepoint: 72 hours;Number of patients with resolution of atleast 2 out of 5 symptoms in all the 3 groups.Timepoint: 72 hours;Number of patients with resolution of sepsis, shock, organ failure in all the 3 groups.Timepoint: 7 days;Number of patients without inotropic supports in all the 3 groups.Timepoint: 7 days;Number of patients without Ventilatory support in all the 3 groups.Timepoint: 72 hours;SurvivalTimepoint: 72 hours and 7 days | — |
Countries
India
Contacts
Public ContactDr V Rajan
Institute of Liver and Biliary Sciences
Outcome results
None listed