Health Condition 1: null- Acute Ischemic stroke patients
Conditions
Interventions
Intervention1: Citicoline: Intravenous citicoline 1000mg immediately after the revascularization therapy (thrombolysis/endovascular thrombectomy) and then every 12 hrs for 3 days followed by oral cit
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Suspected acute ischemic stroke based on clinical and radiographic evidence as determined and documented by the AIIMS stroke team 2. Participants must meet criteria for intravenous thrombolysis or intra-arterial thrombectomy as determined and documented by Stroke Neurologist and Interventional Neuroradiologist at AIIMS 3. Patients must be treated within 6 hours of their initial stroke symptoms onset. 4. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage 2. Known allergic reactions to components Citicoline or contrast allergy 3. CT or conventional MRI evidence of brain tumor, subarachnoid and/or intracerebral and/or intraventricular hemorrhage 4. Previous disorders that may confound the interpretation of the neurological scales 5. Pre existing dementia, when dementia implies a disability, measured as a score of 2 or higher in the previous MRS 6. Patients under current treatment with citicoline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in stroke volume from baseline to week 6Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate at 90 daysTimepoint: 2 years;MRS 0-2 at 90 daysTimepoint: 2 years;NIHSS 0-2 at Day 90Timepoint: 2 years;Barthel Index more than or equal to 95 at 90 daysTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactVishnu V Y
AIIMS New Delhi
Outcome results
None listed