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The Effect of Anaesthetic Drugs on Recovery in Patients Undergoing Cancer surgery

The Effect of Low Dose Ketamine vs Dexmedetomidine Infusions on Recovery Profiles in Patients Undergoing GI Malignancy Surgeries - A Randomised Control Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/02/011880
Enrollment
84
Registered
2018-02-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- GASTRO INTESTINAL MALIGNANCY SURGERIES

Interventions

Intervention1: KETAMINE: Patients will be randomised to receive low dose ketamine infusions @ 0.1 mg/kg/hr + GA + Epidural
ketamine infusion will be started around the time of skin incision Intervention2: DEXMEDETOMIDINE: : Dexmedetomidine IV infusions @ 0.25 mcg/kg/hr + GA + Epidural
dexmedetomidine infusion will be started around the time of skin incision around the time of incision Control Intervention1: NORMAL SALINE: 0.9 % Saline IV infusions @ 5 ml/hr

Sponsors

All India Institute of Medical Sciences Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All adults patients between 18 to 70 years undergoing open GI malignancy surgeries of American Society of Anesthesiologists I & II Surgeries that are expected to last less than 6 hrs

Exclusion criteria

Exclusion criteria: Refusal for the consent Emergency surgeries and re-do surgeries Patients having any coagulopathies Diabetic patients Contraindications to dexmedetomidine and ketamine Contraindications to epidural Patients who has received these drugs previously within one month Known allergic to ketamine and dexmedetomidine. Patients not extubated for >6 hrs after reversal

Design outcomes

Primary

MeasureTime frame
1.To assess the effect of infusion of a low dose of ketamine and dexmedetomidine infusions vs placebo on the time to passage of first flatus and/or stools in patients undergoing GI malignancy surgeries.Timepoint: Post - Operatively 24 hrs to 72 hrs—

Secondary

MeasureTime frame
1. Total intra-operative & post-operative analgesic used (fentanyl & epidural) 2. Post op pain & PONV 3. Duration of ICU stay & time to hospital discharge 4. Time to extubation after reversal 5. Any other adverse eventsTimepoint: post-operatively upto 48 hrs—

Countries

India

Contacts

Public ContactK SABARI KARTHICK

All India Institute of Medical Sciences, Bhubaneswar

misrasatyajeet@gmail.com9438884048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026