Health Condition 1: null- Obsessive Compulsive Disorder
Conditions
Interventions
Intervention1: Cathodal Transcranial Direct Current Stimulation (c-tDCS): Cathode will be placed over the pre-SMA and anode will be placed over the right deltoid. Total ten sessions of tDCS, two sessi
Sponsors
Department of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with Obsessive Compulsive disorder according to ICD 10-DCR diagnostic criteria (F42) 2. Patients diagnosed with treatment resistant OCD defined as non-response to adequate trials (Adequate dose- 60 mg of Fluoxetine equivalent and adequate duration- 10-12 weeks) of at least 2 antiobsessive medications, with or without cognitive-behavioral therapy (CBT) 3. Giving written informed consent
Exclusion criteria
Exclusion criteria: 1.Patients with any other major neuropsychiatric disorder such as schizophrenia or bipolar affective disorder. 2. Patients with any major neurological disorder. 3.Patients with contraindications to tDCS (Metal implant in the head, pacemaker) 4. Patients who have been newly recruited for Cognitive Behavioural Therapy during the period of follow up. 5. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in absolute score in Yale- Brown Obsessive Compulsive Scale Stages of response defined as: Partial response- Greater than 25% but less than 35% Y-BOCS reduction, Full response- 35% or greater reduction of Y-BOCS and CGI 1 or 2, Remission- Less than 16 on Y-BOCS, Recovery- Less than 8 on Y-BOCSTimepoint: Baseline, after 10 sessions of tDCS, after 1 month, after 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of safety of tDCS based on adverse effects questionnaireTimepoint: After each session of tDCS;Effect of tDCS on abstract ability and set shifting, decision making, response inhibition, mental speed, verbal working memory, sustained attention and focused attention based on Wisconsin card sorting test, Go/No-go task, Stroop test, Digit symbol test, Verbal n-back test, Digit vigilance test, Colour trails testTimepoint: Baseline, after 10 sessions of tDCS, after 1 month, after 3 months;Reduction in Hamilton Anxiety Rating Scale score after tDCSTimepoint: Baseline, after 10 sessions of tDCS, after 1 month, after 3 months;Reduction on Hamilton Depression Rating Scale score after tDCSTimepoint: Baseline, after 10 sessions of tDCS, after 1 month, after 3 months | — |
Countries
India
Contacts
Public ContactDr Annesha Mukherjee
Kasturba Medical College, Manipal
Outcome results
None listed