Health Condition 1: null- Dystonic hand tremor Health Condition 2: G252- Other specified forms of tremor
Conditions
Interventions
Intervention1: Botulinum toxin: Botulinum toxin (50U of Onabotulinum Toxin A or equivalent) will be injected intramuscularly into the dystonic/ tremulous muscles under electromyography guidance. Total
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: a) Age >18 years b) Isolated focal/segmental/multifocal dystonia having brachial dystonia with dystonic tremor as defined by the Movement Disorder Society Consensus criteria for tremor (1998)(3) c) On stable dose of medications for tremor (if any) for the past 1 month prior to study enrolment d) Not previously received BoNT for hand dystonia/tremor or last injection at least 4 months prior to study enrolment
Exclusion criteria
Exclusion criteria: a) Clinical evidence of Parkinsonism, cerebellar ataxia b) Hand tremor associated with dystonia in another body part and absent focal hand dystonia (Tremor associated with dystonia) c) Contraindications to BoNT:Neuromuscular junction disorder, anterior horn cell disorder d) Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score on Fahn-Tolosa-Marin scale at 6 weeks after the intervention session.Timepoint: 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Fahn-Tolosa-Marin tremor rating scale Part A component for the upper extremity, Part B for specific motor tasks and Part C for functional disabilities resulting from tremorTimepoint: 6 weeks, 12 weeks;Patient Global Impression of Change scaleTimepoint: 6 weeeks, 12 weeks;Total power of the spectrum on tremor analysisTimepoint: 6 weeks;Writerâ??s Cramp Rating Scale total scoreTimepoint: 6 weeks, 12 weeks | — |
Countries
India
Contacts
Public ContactRoopa Rajan
All India Institute of Medical Sciences
Outcome results
None listed