Health Condition 1: B519- Plasmodium vivax malaria without complication
Conditions
Interventions
Intervention1: PCR validation and genomic analyses in severe and non severe malaria in comparison with healthy volunteer: This proposal aims to validate severe and non-severe malaria samples identifie
Sponsors
Indian Institute of Technology
Eligibility
Inclusion criteria
Inclusion criteria: 1.Participants of either sex aged 18-65 years both inclusive 2.Either gender 3.Severe and Non-severe malaria infectionsas per the WHO guidelines. 4.Healthy volunteers as judged by medical history clinical examination and laboratory investigations 5.Patients or their legally accepted representatives willing to provide written informed consent
Exclusion criteria
Exclusion criteria: Patients with history of significant systematic disease like autoimmune disorders chronic liver diseases psychiatric illness and bleeding disorders etc As judged by history and physical examination A female patient who is pregnant at enrolling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PCR of all the severe non-severe samples identified microscopically to validate for the presence of single (either P falciparum or P vivax) as well as multiple (both P falciparum and P vivax) parasite species infectionsTimepoint: Single time | — |
Secondary
| Measure | Time frame |
|---|---|
| Genomic analyses (Single Nucleotide Polymorphisms and genotyping assays) of pro and anti-inflammatory cytokines acute phase genes and sequestration factor Correlation of the SNPs identified in the host inflammatory (HI) genes (exons) as well as the promoter regions with disease severity Whether these host inflammatory genes can be potential prognostic biomarkers for malaria testing? Timepoint: single time | — |
Countries
India
Contacts
Public ContactDr Nithya Gogtay
KEM Hospital
Outcome results
None listed