Health Condition 1: null- Patients undergoing Cardiac surgery with right heart failure Health Condition 2: I081- Rheumatic disorders of both mitraland tricuspid valves
Conditions
Interventions
None listed
Sponsors
Sri Jayadeva Insitute of Cardiovascular Sciences and Research
Ravi Sundaresan
Eligibility
Inclusion criteria
Inclusion criteria: 50 consecutive adult (greater than 18 years) normotensive and 50 hypertensive tricuspid regurgitation patients for this study. All these patients are those coming for routine cardiac surgery for their left and right sided lesions as per standard criteria with cross consultation of cardiac surgeons and cardiologists as far as indications for surgery goes guided by standard AHA/ACC, European and Indian guidelines. All patients will receive conventional cardiac surgery on cardiopulmonary bypass with no change in the routine practice of the hospital. For normal controls we will be taking 50 biopsies from right ventricle from hearts which have been donated for homograft banking or from forensic autopsies where there is no history or pathological evidence of pre-existing right heart failure ie death due to unrelated causes.
Exclusion criteria
Exclusion criteria: We will exclude patients who have concomitant coronary artery disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will measure the expression profile, activity and localization of GRKs in control versus normotensive and hypertensive right heart failure patients. We will quantify the expression and localization of βARs in the myocardium of control versus normotensive and hypertensive right heart failure patients. Our findings will provide the molecular cues as to why the hypertensive right heart failure patients develop inotropic resistance. Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment stategies may be designed for patients who have developed ionotropic resistance by targeting GRKSTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Prasanna Simha Mohan Rao
Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India
Outcome results
None listed