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A study to compare the pain relief of two medications morphine and loperamide applied on the wound

Comparison of morphine and loperamide with intrasite gel in treatment of painful ulcers: A prospective, double blind, randomized, cross-over study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011621
Enrollment
20
Registered
2018-01-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Painful cutaneous ulcers in diabetes and other health conditions Health Condition 2: L899- Pressure ulcer of unspecified site

Interventions

Intervention1: Dr Vishwajeet: Junior Resident, Dept of Anaesthesia, KIMS, Hubballi Intervention2: Dr Milon V M: Senior Resident Dept of Anaesthesia KIMS Hubli Intervention3: Loperamide hydrochlorid

Sponsors

Karnataka Institute of Medical Sciences Hubli
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age > 18 years. 2. Patients with painful cutaneous lower limb ulcers with VAS score >5. 3. Ulcer 4. Patients giving written informed consent to be included in the study groups.

Exclusion criteria

Exclusion criteria: 1. Uncooperative patients. 2. Hemodynamically unstable patients, patients with liver and hepatic diseases. 3. Patients with unhealthy ulcers and extensive debridement needed. 4. Patients with allergy to any of the study drugs and intrasite formulation. 5. Patients already on oral or intravenous opiod medications.

Design outcomes

Primary

MeasureTime frame
visual analogue scoreTimepoint: 3-10—

Secondary

MeasureTime frame
need of rescue analgesiaTimepoint: o or 1—

Countries

India

Contacts

Public ContactMilon Vasant Mitragotri

Karnataka institute of medical sciences, Hubli

drjyothib1@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026