Health Condition 1: null- The study will include adult patients (age 18 years) with newly diagnosed CAD for which angioplasty is done with stents
Conditions
Interventions
None listed
Sponsors
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: 1. >=18 years of age, male, or female 2. Patients with newly diagnosed CAD for which coronary angioplasty is done with stent (s) 3. Patients on dual antiplatelet therapy including aspirin and one of the P2Y12 inhibitors i.e. clopidogrel, ticagrelor or prasugrel.
Exclusion criteria
Exclusion criteria: 1. Patients with the history of CAD, CABG and/or angioplasty 2. Hb 3. Patient with decompensated heart failure 4. Patients with metabolic syndrome 5. History of chronic kidney disease 6. History of malignancy 7. History of psychiatric illness 8. History of chronic hepatic disease 9. History of bleeding diathesis 10. Pregnancy and lactation 11. Any other medication that might effects of study drugs eg: rifampicin, phenytoin, carbamazepine 12. Any other medical condition that, in the opinion of the investigator, may be an unacceptable additional risk to the patient 13. Patients on antithrombotic agents including antiplatelet drugs, anticoagulants and thrombolytic drugs for any other reason 14. Patients with history of CVA, TIA, acute or chronic pulmonary embolism or any valvular heart disease for which he/she was on antithrombotic, anticoagulants and antiplatelet drugs 15. Patientâ??s participation in any other clinical trial with an investigational treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of antiplatelet drugs resistance in the recruited populationTimepoint: 2 Year (After angioplasty procedure) | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of adverse cardiac outcomes (MACE) in post angioplasty patients in view of dual antiplatelet drug resistanceTimepoint: 2 Year (After angioplasty procedure);Assessment of P2Y12 platelet inhibitors associated mortality and comparative mortality analysis between three agents (Clopidogrel, ticagrelor and Prasugrel)Timepoint: 2 Year (After angioplasty procedure) | — |
Countries
India
Contacts
Public ContactDr Tom Devasia
Melaka Manipal Medical College
Outcome results
None listed