Health Condition 1: null- Parkinsons Disease Health Condition 2: G20- Parkinsons disease
Conditions
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia); 2. PD patients of both gender with H&Y stage from 1 to 2. 3. PD patients between age 45 to 75 on stable medication for at least 30 days
Exclusion criteria
Exclusion criteria: 1. Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes; 2. History of surgery on brain for any indication, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length; 3. Family (1st degree relatives) history of epilepsy; 4. History of schizophrenia, schizoaffective disorder, other psychosis, claustrophobia; rapid-cycling bipolar illness, alcohol/drug abuse within the past year; 5. Need for rapid clinical response due to conditions such as psychosis, or suicide tendency; 6. Patients with uncontrolled hypertension and diabetes and other uncontrolled medical illness. Patients with hypertension or diabetes would be included only if they are stable on medication for last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| i. To compare the status of cortical plasticity between two treatment groups (M1, SMA) using FDG-PET. Timepoint: Baseline 0 day Post Sham at 4th week Post Real at 8th week [Baseline:-After recruitment Post-Sham:-After 4 sessions of Sham TMS Post-Real:- After 4 sessions of Real TMS.] | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the clinical condition of the patients in the two treatment groups on the basis of UPDRS. Timepoint: Baseline 0 day Post Sham at 4th week Post Real at 8th week [Baseline:-After recruitment Post-Sham:-After 4 sessions of Sham TMS Post-Real:- After 4 sessions of Real TMS.] | — |
Countries
India
Contacts
Public ContactVinay Goyal
All India Institute of Medical Sciences
Outcome results
None listed