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Tranexemic acid for bloodless root canal

Establishing clinical protocol for the use of Tranexamic acid to control pulpal bleeding & facilitate instrumentation during access cavity preparation.

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011557
Enrollment
500
Registered
2018-01-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients requiring root canal therapy in posterior teeth

Interventions

Intervention1: Tranexamic acid soaked cotton pellet: Placement of a cotton pellet saturated with 1mg/ ml of Tranexamic acid solution in the pulp chamber. Intervention2: Tranexamic acid using injection

Sponsors

Dr Roshni
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy adult patients 2. Maxillary and mandibular molars 3. Vital teeth indicated for root canal for endodontic, periodontal and prosthodontal reasons 4. Moderate to severe bleeding from the pulp chamber either from a normal/ hyperemic pulp on initiating access cavity preparation

Exclusion criteria

Exclusion criteria: 1. Patients on anticoagulants 2. Active intravascular clotting 3. Subarachnoid hemorrhage 4. Hypersensitivity to Tranexamic acid 5. Pregnancy of lactating mothers 6. Upper renal tract bleeding 7. Hemorrhagic diathesis 8. Occular conditions like defective color vision

Design outcomes

Primary

MeasureTime frame
Most effective method of application of Tranexamic acid to control pulpal bleeding during access cavity preparationTimepoint: 2-5 minutes

Secondary

MeasureTime frame
To assess the effect of intrapulpal Tranexamic acid on bleeding and clotting time of the patientTimepoint: 30 minutes;To check for bleeding on re-instrumentation and need for re- application of Tranexamic acidTimepoint: 2-5 minutes;To check volume of pulpal bleeding by gravitimetric methodTimepoint: 2-5 minutes

Countries

India

Contacts

Public ContactDr Mamta Kaushik

Army College of Dental Sciences

roshni3077@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026