Effect of esmolol- lignocaine infusion in improving cardiac functions and decreasing irregular heart beat post operatively when given during cardiac bypass surgeries.

Effect of on-pump esmolol- lignocaine infusion on post cardio-pulmonary bypass cardiac arrhythmias and function

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011555

Enrollment

Registered

2018-01-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: null- patients undergoing cardiac surgeries under cardiopulmonary bypass

Interventions

Intervention1: esmolol- lignocaine infusion: esmolol- lignocaine infusion in the test group @ 40 mcg/kg/min during the cross clamp time in CPB Control Intervention1: normal saline: as a placebo agent

Eligibility

Inclusion criteria

Inclusion criteria: patients with cardiac disease undergoing cardiac surgery under cardio-pulmonary bypass with ejection fraction of <50% for Coronary artery bypass graft surgeries And <60% for Aortic regurgitation and Mitral regurgitation valve repair surgeries .

Exclusion criteria

Exclusion criteria: Patients not willing for the study,with asthma, existing atrial flutter or fibrillation, allergy to esmolol or lignocaine, hepatic or renal dysfunction.

Design outcomes

Primary

Measure	Time frame
To compare the incidence of arrhythmias after CPB either by using HOLTERS monitor or saved ECG record in the ICU monitor during first 24 hours in patients receiving esmolol-lignocaine infusion on CPB with control group receiving placebo infusion.Timepoint: first 24 hours post CPB.	—

Secondary

Measure	Time frame
To compare pain score,analgesia requirement, inotropic requirement and mechanical ventilation duration post operatively after CPB separation for first 24 hours.Timepoint: first 24 hours post CPB	—

Countries

India

Contacts

Public ContactDr Virendra K Arya

PGIMER

aryavk_99@yahoo.com9876644719

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026