To compare the amount of drug absorbed when deposited above or below the sheath covering the nerves lies above the collar bone under ultrasound guidance

A randomized comparison of Plasma Lignocaine concentration following extrafascial vs subfascial injection during USG guided supraclavicular brachial plexus block

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011539

Enrollment

Registered

2018-01-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing elbow or below elbow surgeries

Interventions

Intervention1: Group SF: 20 ml of 2% lignocaine with 5mcg/cc AdrenalineI deposited inside the brachial plexus sheath under ultrasound guidance Control Intervention1: Group EF: 20 ml of 2% lignocaine w

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 and weighing 50-60kg patients undergoing elbow or below elbow surgeries

Exclusion criteria

Exclusion criteria: H/o any co-morbidities, coagulopathy, Local anaesthetic allergy, infection at the site of block, preexisting neurological deficit of the surgical limb

Design outcomes

Primary

Measure	Time frame
Peak Plasma ConcentrationTimepoint: Pre block (Baseline), 10, 20, 30, 45, 60, 90, 120 minutes post Brachial plexus block	—

Secondary

Measure	Time frame
Complete Motor BlockadeTimepoint: every 3 minutes for first 15 minutes and then every 5 minutes till scale 0 sensory and motor blockade or 40 minutes which ever earlier;Complete Sensory BlockadeTimepoint: every 3 minutes for first 15 minutes and then every 5 minutes till scale 0 sensory and motor blockade or 40 minutes which ever earlier;Duration of analgesiaTimepoint: 2, 4, 6, 24 post-operative hours from time 0 or till sensory level 2 and motor level 2 whichever earlier ;Time to Peak Plasma ConcentrationTimepoint: Pre block (Baseline), 10, 20, 30, 45, 60, 90, 120 minutes post Brachial plexus block	—

Measure

Time frame

Complete Motor BlockadeTimepoint: every 3 minutes for first 15 minutes and then every 5 minutes till scale 0 sensory and motor blockade or 40 minutes which ever earlier;Complete Sensory BlockadeTimepoint: every 3 minutes for first 15 minutes and then every 5 minutes till scale 0 sensory and motor blockade or 40 minutes which ever earlier;Duration of analgesiaTimepoint: 2, 4, 6, 24 post-operative hours from time 0 or till sensory level 2 and motor level 2 whichever earlier ;Time to Peak Plasma ConcentrationTimepoint: Pre block (Baseline), 10, 20, 30, 45, 60, 90, 120 minutes post Brachial plexus block

—

Countries

India

Contacts

Public ContactJaya V

Mahatma Gandhi Medical College and Research Institute

drsiva95@gmail.com9442505567

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026