Health Condition 1: null- PALMOPLANTAR WART
Conditions
Interventions
Intervention1: bleomycin sulphate: freeze dried powder to be reconstituted with distilled water
Control Intervention1: candy skin testing antigen: 2% w/v
Sponsors
INDIAN COUNCIL OF MEDICAL RESEARCH
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age- Adult males and females aged 18-65 years. 2. Multiple plantar warts diagnosed on the basis of history and physical examination by two dermatologists. Palmoplantar warts will be defined as sharply defined, hyperkeratotic rough lesions with loss of epithelial ridges over the surface of the lesion with a smooth collar of thickened horn present over the palmar or plantar surfaces. 3. Untreated or no treatment in the last four weeks.
Exclusion criteria
Exclusion criteria: 1. Known immune-compromised state such as history of HIV infection, on steroids and other immunosuppressive drugs. 2. Past history of immunotherapy or bleomycin sulphate. 3. Warts measuring more than 20cm2 in size. 4. Local site infection. 5. Pregnant and lactating females. 6. Any history of chronic cardiac, renal and pulmonary illness, peripheral vascular disease, Raynaudâ??s disease. 7. Unable to give informed consent. 8. Allergy to components of candida antigen or bleomycin sulphate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clearance of wartsTimepoint: Four weeks after the last dose of agent | — |
Secondary
| Measure | Time frame |
|---|---|
| CLEARANCE OF DISTANT UNTREATED WARTTimepoint: 4 and 12 weeks after the last dose of agent;Delayed clearance of unresolved wartsTimepoint: 12 weeks after the last dose of agent;Recurrence of completely cleared lesionsTimepoint: 12 weeks after the last dose of agent | — |
Countries
India
Contacts
Public ContactMANIK AGGARWAL
All India Institute of Medical Sciences
Outcome results
None listed