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A study to investigate the effect of different doses of Pregabalin on severe muscle and limb jerks caused by etomidate (an Anaesthetic agent).

Effect of different doses of pregabalin on prevention of etomidate induced myoclonus-A Prospective randomized controlled trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011522
Enrollment
90
Registered
2018-01-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- American society of Anesthesiologists physical status I/II, 18-60 years of age, undergoing elective surgeries under planned general anaesthesia

Interventions

Intervention1: Pregabalin 75 mg: 1 Pregabalin 75 mg capsule and 1 placebo capsule administered 2 hours before induction of anaesthesia Intervention2: Pregabalin 150 mg: 2 Pregabalin 75 mg capsules adm

Sponsors

Shri Guru Ram Rai Institute of Medical and Health Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Undergoing elective surgeries under planned general anaesthesia American society of anesthesiologists physical status I/II

Exclusion criteria

Exclusion criteria: Requiring rapid sequence intubation Allergy to any of the study drug Pregnant/lactating mothers Chronic opioid/antidepressant/clonidine/anticonvulsant/gabapentin/beta blocker/pregabalin therapy impaired renal functions

Design outcomes

Primary

MeasureTime frame
Incidence of myoclonusTimepoint: 2 minutes after administration of etomidate—

Secondary

MeasureTime frame
Pregabalin induced side effectsTimepoint: 2 hours after administration of Pregabalin—

Countries

India

Contacts

Public ContactDr Priyanka Gupta

Shri Guru Ram Rai Institute of Medical and Health Sciences

priyankamalhotra82@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026