Health Condition 1: null- pancreatic and Periampullary cancer
Conditions
Interventions
Intervention1: Tumour site: patients will undergo intraoperative wedge biopsy from the tumor
Control Intervention1: Normal parenchyma: A biopsy from normal pancreatic parenchyma will also be obtained
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1) All patients presenting with resectable and bulky periampullary and pancreatic head tumors planned for pancreaticoduodenectomy will be included in the study.
Exclusion criteria
Exclusion criteria: 1. Unresectable (locally advanced/metastatic) disease 2. Patients refusing consent for the study 3. Synchronous malignancy elsewhere 4. Patients treated with chemo/radiotherapy 5. Patients subjected to an earlier surgical exploration without tumor resection 6. Patients unfit for surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study whether acute surgical hypoxia during pancreaticoduodenectomy, done for pancreatic and periampullary adenocarcinoma, is related to the generation of stemness.Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To study which genetic markers of stemness are induced by acute surgical hypoxia 2) To compare whole transcriptome of the intraoperative biopsy specimens obtained at different time pointsâ??. Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactShailesh Vinayak Shrikhande
Tata Memorial Hospital
Outcome results
None listed