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effects of atropine in suppressing negative haemodynamic effects

A prospective randomised study to assess whether prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and fentanyl.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011470
Enrollment
40
Registered
2018-01-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients undergoing surgery under general anaesthesia

Interventions

Intervention1: Atropine: Atropine 0.6mg Intravenous route Single dose Before the induction of anaesthesia Monitored for 15 mins Control Intervention1: Normal saline: Normal saline 1 cc Intravenous r

Sponsors

Head of the department
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients posted for elective surgery 2 ASA I and II

Exclusion criteria

Exclusion criteria: 1 ASA III and IV 2 Patients with contraindications of atropine 3 Patients with IHD/CAD/DIABETIC NEUROPATHY 4 Patients with ECG showing tachyarrythmias 5 Emergency surgeries 6 Mallampatti grade III and IV 7 BMI >35 8 Anticipated difficult airway

Design outcomes

Primary

MeasureTime frame
Atropine attenuates the fall in BP HR and MAP during induction of anaesthesia with propofol and fentanylTimepoint: Starting point Time of induction with propofol and fentanyl End point Monitored every minute till 15 mins after induction of anaesthesia—

Secondary

MeasureTime frame
nilTimepoint: nil—

Countries

India

Contacts

Public ContactS Dinesh kumar

Kanyakumari govt medical college

edwardjohnson2310@gmail.com9443392974

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026