Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified
Conditions
Interventions
None listed
Sponsors
Chest Research Foundation
Eligibility
Inclusion criteria
Inclusion criteria: ï?· Healthy non-smoker o Be at least 40 years of age o Provide written informed consent o Never smoker and not exposed to biomass for >10 years o No major abnormality on clinical examination o Normal spirometry, FEV1/FVC >0.70 ï?· Healthy smoker o Be at least 40 years of age o Provide written informed consent o Be smoking tobacco in the form of bidi or cigarettes for at least 10 pack years o No major abnormality on clinical examination o Normal spirometry, FEV1/FVC >0.70 4 ï?· Healthy Biomass user o Be at least 40 years of age o Provide written informed consent o Be exposed to biomass for at least 10 fuel-years (exposure of 2hrs/day for 10 years) after adulthood o No major abnormality on clinical examination o Normal spirometry, FEV1/FVC >0.70 ï?· Tobacco smoking COPD o Be at least 40 years of age o Provide written informed consent o Be smoking tobacco in the form or bidi or cigarettes for at least 10 pack-years o Have a clinical diagnosis of COPD (GOLD stage I to III) and post-bronchodilator FEV1/FVC ratio ï?· Non-smoking COPD o Be at least 40 years of age o Provide written informed consent o Be exposed to biomass for at least 10 fuel-years after adulthood o Have a clinical diagnosis of COPD (GOLD stage I to III): post-bronchodilator FEV1/FVC ratio o Never smoker o FEV1 reversibility <400 mL to rule out asthma
Exclusion criteria
Exclusion criteria: Severe COPD patients would be excluded as the process of sputum induction may worsen their condition ï?· History of lung condition other than COPD including respiratory infectious diseases like tuberculosis, asthma, interstitial lung disease, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mitochondrial respiration in PBMCs of healthy and COPD patientsTimepoint: 1 | — |
Secondary
| Measure | Time frame |
|---|---|
| NoneTimepoint: 1 | — |
Countries
India
Contacts
Public ContactAmit Agarwal
Chest Research Foundation
Outcome results
None listed