A study to compare the effects of two treatments for mild to moderately severe knee osteoarthritis:injection within joints of hyaluronic acid and of dextrose,both within and around joints.

Comparative study of intra articular high molecular hyaluronic acid and para articular dextrose prolotherapy in mild to moderate knee osteoarthritis.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011431

Enrollment

Registered

2018-01-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Osteoarthritis of knee

Interventions

Intervention1: 12.5% dextrose: 25% dextrose diluted with equal volume of 2% preservative free lignocaine,2 ml intra artricularly and 0.5 ml para articularly at osteo tendinous junction. Only one treat

Eligibility

Inclusion criteria

Inclusion criteria: 1.Knee pain 2.Kellgren Lawrence grade I II III

Exclusion criteria

Exclusion criteria: 1.Systemic disease 2.On anticoagulants 3.Previous intra articular steroid injection 4.Knee inflammation/ infection 5.Use of steroids in past two weeks

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale (VAS) Timepoint: two months	—

Secondary

Measure	Time frame
Western Ontario and Mcmaster University Arthritis Index (WOMAC) Timepoint: 2 MONTHS	—

Countries

India

Contacts

Public ContactRamapati Sanyal

ESI Institute of Pain Management

santi.dasgupta10@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026