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Study of a new technique to analyse chemicals released by our own cells to identify latent tuberculosis

Role of intracellular cytokine flow cytometry in assessing tuberculosis specific cytokines to differentiate between active and latent tuberculosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/01/011369
Enrollment
50
Registered
2018-01-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Active pulmonary tuberculosis

Interventions

Control Intervention1: nil: nil

Sponsors

Manipal McGill Center for Infectious Diseases
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with active pulmonary TB, latent TB, successfully treated TB and healthy controls as per the standard definitions

Exclusion criteria

Exclusion criteria: a. Pregnant women, patients with HIV/AIDS, autoimmune disorders, malignancy, patients on chemotherapy or radiotherapy b. Extra-pulmonary TB

Design outcomes

Primary

MeasureTime frame
ICCFC may be used as a discriminating test between active and latent TB. This will have important implications in identifying individuals with latent TB for preventive chemotherapy. Additionally, a biomarker based test for active TB is much needed to close the diagnostic gap and delay in TB diagnosis.Timepoint: 9 months—

Secondary

MeasureTime frame
Cytokine expression pattern in MTB antigen stimulated T cells will help in understanding the disease pathogenesis. An optimal gating strategy for ICCFC will be drafted. Timepoint: 9 months—

Countries

India

Contacts

Public ContactSindhura Lakshmi Koulmane Lakshminarayana

Manipal academy of higher education

sindhuralakshmikl@yahoo.co.in8095136096

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026