comparison between different combination of drugs such 0.75% Ropivacaine fentanyl and 0.75% ropivacaine , fentanyl and magnesium sulphate in epidural anesthesia in lower limb surgeries

THE COMPARATIVE STUDY OF 0.75% ROPIVACAINE WITH FENTANYL VS 0.75% ROPIVACAINE, FENTANYL AND MAGNESIUM SULPHATE IN EPIDURAL ANESTHESIA FOR LOWER LIMB SURGERIES

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011315

Enrollment

Registered

2018-01-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA Grade II or III individuals being posted for elective lower limb surgeries

Interventions

Intervention1: Inj.0.75% ropivacaine fentanyl: Inj.0.75% ropivacaine fentanyl in epidural anesthesia in lower limb surgeries Intervention2: Inj.0.75% ropivacaine fentanyl mgso4: Inj.0.75% ropivacain

Eligibility

Inclusion criteria

Inclusion criteria: A total of 60 patients of either sexes, age group between 18-65 yrs, body weight between 40-80 Kg and ASA grade I&II were chosen surgerieswho were posted for elected lower limb

Exclusion criteria

Exclusion criteria: Patients of renal, pulmonary, cardiovascular, neurological, neuromuscular diseases deranged liver function test were excluded from our study. Any contraindication to epidural anesthesia as local site infection, bleeding tendencies, vertebral anomalies, Sepsis, Raised Intracranial pressure, allergy to local anesthetic agents, peripheral neuropathy, patientâ??s refusal and physical dependence on narcotics were also excluded from the study

Design outcomes

Primary

Measure	Time frame
when mgso4 added to 0.75% Ropivacaine and fentanyl for epidural anesthesia, it brings about better quality, faster onset, and longer duration of sensory and motor blockade when compared with ropivaCaine fentanyl aloneTimepoint: variables block characteristics such as:-Time for achieving onset of analgesia, Time for achieving T10 sensory blockade ,Median and maximum level of sensory blockade achieved, Time for achieving Motor Blockade ,Time for complete motor recovery ,Time for requirement of first epidural top up from initial medication (in min)	—

Measure

Time frame

when mgso4 added to 0.75% Ropivacaine and fentanyl for epidural anesthesia, it brings about better quality, faster onset, and longer duration of sensory and motor blockade when compared with ropivaCaine fentanyl aloneTimepoint: variables block characteristics such as:-Time for achieving onset of analgesia, Time for achieving T10 sensory blockade ,Median and maximum level of sensory blockade achieved, Time for achieving Motor Blockade ,Time for complete motor recovery ,Time for requirement of first epidural top up from initial medication (in min)

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Secondary

Measure	Time frame
better hemodynamic and side effect profile with 0.75% ropivacaine fentanyl and mgso4 than with ropivacaine and fentanyl in epidural anesthesiaTimepoint: mean arterial pressure heart rate and spo2 was observed at preoperatively 0, 5, 10,15,20, 30 ,45,60,90,120,150,180,210,240 minutes till the end of surgery and postoperatively while shifting the patient.side effect profile was checked at all time intervals after administering the drug to the patient.	—

Measure

Time frame

better hemodynamic and side effect profile with 0.75% ropivacaine fentanyl and mgso4 than with ropivacaine and fentanyl in epidural anesthesiaTimepoint: mean arterial pressure heart rate and spo2 was observed at preoperatively 0, 5, 10,15,20, 30 ,45,60,90,120,150,180,210,240 minutes till the end of surgery and postoperatively while shifting the patient.side effect profile was checked at all time intervals after administering the drug to the patient.

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Countries

India

Contacts

Public ContactDr arushi gupta

King Georges Medical University Lucknow

tanmayanesthesia@gmail.com7052525423

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026