Comparative evaluation of efficacy of two bone grafts Sybograf C (Nanocrystalline Hydroxyapatite with natural Collagen) and Sybograf (Nanocrystalline Hydroxyapatite) in treatment of intrabony defects in alveolar bone in chronic periodontitis patients.

Comparative Clinical and Radiographic Evaluation of the Effect of Nano-crystalline Hydroxyapatite with Natural Collagen- Sybograf C and Nano-crystalline Hydroxyapatite -Sybograf in the Treatment of Intrabony Defects in Chronic Periodontitis Patients.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011302

Enrollment

Registered

2018-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic Periodontitis

Interventions

Intervention1: Bone grafts: In chronic periodontitis patients with intra-bony defects, open flap debridement will be done. the intra-bony defect will be thoroughly debrided and one of the two bone gra

(iii) post-operative adsorption of hydroxyapatite, if any, is slight and slow and is replaced by bone

The clinical disadvantages of hydroxyapatite particles are that they tend to not stay in place in a bleeding site, and there is a relatively slow restoration of bone within the assemblage of particles

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age group between 20-60years 2. Diagnosis with chronic periodontitis 3. Patients in good systemic health with no contraindication to periodontal surgery 4. Patients having intrabony defects with pocket depths of >5mm and with radiographic evidence of vertical / angular bone loss in the affected sites. 5. Patients who had not received any type of periodontal therapy for the past 6 months 6. Patients not taking any immuno-suppressive drugs like corticosteroids 7. Involved teeth to be vital and asymptomatic

Exclusion criteria

Exclusion criteria: 1. One â?? wall osseous defects. 2. Patients suffering from any systemic diseases or with compromised immune system. 3. Patients with a known history of allergy to doxycycline or Chlorhexidine or any other medicine be used in the study. 4. Patients showing unacceptable oral hygiene compliance during / after the phase I therapy. 5. Patients taking any drug known to cause gingival enlargement. 6. Pregnant and/or lactating mothers. 7. Patients who were smokers or had tobacco in any other form. 8. Endodontically treated teeth. 9. Patient on anticoagulant therapy 10. Patient with bleeding disorders .

Design outcomes

Primary

Measure	Time frame
1. Plaque Index (P.I.) (Turskey-Gilmore-Glickman Modification of Quigley Hein). 2. Gingival Index (G.I.) (Loe & Silness, 1963). 3. Probing Pocket Depth (PPD). 4. Clinical Attachment Level (CAL). Timepoint: 1. Plaque Index (P.I.) (Turskey-Gilmore-Glickman Modification of Quigley Hein)-evaluation at Baseline and after 1 month, 3 months, 6 months. 2. Gingival Index (G.I.) (Loe & Silness, 1963)- evaluation at Baseline and after 1 month, 3 months, 6 months. 3. Probing Pocket Depth (PPD).evaluation at Baseline and after 3 months, 6 months. 4. Clinical Attachment Level (CAL).evaluation at Baseline and after 3 months, 6 months.	—

Measure

Time frame

1. Plaque Index (P.I.) (Turskey-Gilmore-Glickman Modification of Quigley Hein). 2. Gingival Index (G.I.) (Loe & Silness, 1963). 3. Probing Pocket Depth (PPD). 4. Clinical Attachment Level (CAL). Timepoint: 1. Plaque Index (P.I.) (Turskey-Gilmore-Glickman Modification of Quigley Hein)-evaluation at Baseline and after 1 month, 3 months, 6 months. 2. Gingival Index (G.I.) (Loe & Silness, 1963)- evaluation at Baseline and after 1 month, 3 months, 6 months. 3. Probing Pocket Depth (PPD).evaluation at Baseline and after 3 months, 6 months. 4. Clinical Attachment Level (CAL).evaluation at Baseline and after 3 months, 6 months.

—

Secondary

Measure	Time frame
Radiographic defect depth and bone fillTimepoint: Radiographic defect depth and bone fill to be evaluated at baseline and after 6 months	—

Countries

India

Contacts

Public ContactDr Abhinav Deshpande

Nair Hospital Dental College

maladixit25@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026