Health Condition 1: null- Those, with HbA1c more than or equal to 6.5% and fasting glucose more than or equal to 126 mg/dl are included Health Condition 2: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Glutathione: Individuals are included in one
of the three groups 1. Control
healthy nondiabetic 2. Diabetic
without glutathione
supplementation 3. Diabetic
with glutathione
supplementat
Sponsors
Savitribai Phule Pune University
Eligibility
Inclusion criteria
Inclusion criteria: For Control non-diabetic individuals those with HbA1c less than 6.5% and fasting glucose less than 126 mg/dl are included. For diabetic individuals those with HbA1c more than or equal to 6.5% and fasting glucose more than or equal to 126 mg/dl are included
Exclusion criteria
Exclusion criteria: Pregnant women, individuals suffering from infection, inflammation or malignant disease, heart abnormality, those addicted to smoking/or drinking and those receiving antioxidants are excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Does glutathione supplementation over 6 months result in at least 10% increase in blood GSH levels? Does GSH supplementation aid in lowering fasting and post prandial glucose concentrations in diabetics due to anti-diabetic therapy and also HbA1c by an additional 0.1mmol/L?Timepoint: 0, 3, 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Whether SNPs in glutathione synthase gene have any effect on its basal concentrations found in blood?Timepoint: 3 month | — |
Countries
India
Contacts
Public ContactSaroj Ghaskadbi
Savitribai Phule Pune University
Outcome results
None listed