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Study on the effect of combination of pain killers on pain relief during and after the surgery

Effect of multimodal perioperative analgesia on stress response to surgery and on post-operative pain score

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011229
Enrollment
42
Registered
2018-01-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- American Society of Anapatientsesthesiologists Class I and II

Interventions

Intervention1: Group A: (MMA group/study group): Received intravenous diclofenac sodium 75mg, paracetamol 1gm, and clonidine 0.75µg/kg, and local infiltration 20ml (bupivacaine 0.25% with adrenalin

Sponsors

Dr Savitha K S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Both sexes 2. BMI (Body Mass Index) 18 to 30 3. Patients undergoing lumbar spine surgery 4. ASA physical status I and II

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Patients with bronchial asthma 3. Patients with history of drug allergy.

Design outcomes

Primary

MeasureTime frame
To assess the difference in serum cortisol and random blood sugar between MMA regime and the conventional analgesic regime in patients undergoing lumbar spine surgery.Timepoint: Two blood samples were drawn; one just before tracheal tube placement and another one 30 min following skin incision for random serum cortisol and random blood sugar.

Secondary

MeasureTime frame
To compare post extubation sedation and visual analogue score (VAS) between the two groups.Timepoint: Post operative sedation and pain score were assessed at 5min and 30min post-extubation respectively.;To compare the incidence of adverse effects (perioperatively:bradicardia and bronchospasm, postoperatively: respiratory depression, nausea and vomiting ) between the two groups.Timepoint: Bradicardia and bronchospasm were looked after administration of of each drug preoperatively and throught the surgery. Respiratory depression, nausea and vomiting were looked for in the postoperative period

Countries

India

Contacts

Public ContactDr Savitha K S

St Johns Medical College & Hospital

drsavitha_ks@yahoo.com9844638121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026