Does treatemnt with Vitamin D and Calcium help patients with Steroid Sensitive Nephrotic Syndrome ?

A Randomized Controlled Trial to assess the effect of Vitamin D deficiency and supplementation on Bone Mineral Density in steroid sensitive nephrotic syndrome

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/01/011225

Enrollment

Registered

2018-01-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with Steroid Sensitive Nephrotic Syndrome in relapse at recruitment.

Interventions

Intervention1: Cholecalciferol (Vitamin D3): Vitamin D3: 60,000 units per orally weekly for 4 weeks if serum 25 hydroxycholecalciferol levels less than 30ng/ml Intervention2: Calcium carbonate: 250 mg

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with diagnosed steroid sensitive nephrotic syndrome 2. Age group: 2 to 14 years 3. Consecutive patients included during active NS episode 4. Urine protein more than 2+ for 3 consecutive days and urine protein creatinine ratio > 2 at recruitment.

Exclusion criteria

Exclusion criteria: 1. Steroid Resistant nephrotic syndrome 2. Hospitalised patients 3. Any other acute or chronic illness 4. Patients with any bone deformities or symptoms related to the musculoskeletal system

Design outcomes

Primary

Measure	Time frame
Bone mineral content and densityTimepoint: at recruitment and post intervention after 6 months.	—

Secondary

Measure	Time frame
Nephrotic Relapse rateTimepoint: over 6 months;renal ultrasoundTimepoint: after 6 months;serum 25 hydroxycholecalciferol levelsTimepoint: at recruitment and post intervention 6 weeks and 6 months;Serum calcium and urinary calcium creatinine ratioTimepoint: at recruitment and post intervention 6 weeks and 6 months	—

Countries

India

Contacts

Public ContactDr Sushmita Banerjee

Institute of Child Health, Kolkata

asban@vsnl.com9830023975

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026