Health Condition 1: O369- Maternal care for fetal problem, unspecified
Conditions
Interventions
Intervention1: aspirin 75 mg: using aspirin 75 mg before 14 weeks pregnancy
Control Intervention1: aspirin 150 mg: using aspirin 150 mg before 14 weeks
Control Intervention2: placebo: inert sucrose
Sponsors
Intramural grant
Eligibility
Inclusion criteria
Inclusion criteria: 1.History : chronic hypertension /past history of severe PE/ past history of Eclampsia/ past history of severe intrauterine growth retardation with normal fetal morphology 2. Mean arterial pressure of more than 90th centile 3.Uterine artery raised pulsatality index of more than 90th centile
Exclusion criteria
Exclusion criteria: Maternal history: 1. Known case of Antiphospholipid antibody syndrome ,Thrombophillia. 2.Maternal medical diseases: peptic ulcer disease, bleeding disorder, chronic kidney disease. Present pregnancy: 1. Maternal thrombocytopenia ( platelet count 2. History of bleeding per vaginum 3. Fetus diagnosed with malformations/ anomaly/ aneuploidy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess differences in outcome between prophylactic uses of low-dose 150 mg aspirin versus 75 mg aspirin versus placebo. Timepoint: 22 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To document effect of different doses of aspirin on maternal (Incidence of early PE with delivery 34 weeks, placental abruption, eclampsia) and fetal (intrauterine growth retardation and stillbirth) outcomes 2. To assess the correlation of various predictors(inclusion criteria) of PE with fetomaternal outcomes. Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactNamrata Kumar
Doctor
Outcome results
None listed