Health Condition 1: null- Breast cancer
Conditions
Interventions
Intervention1: Core biopsy: An ultrasound guided core biopsy will be done in patients having complete clinical and radiological response to chemotherapy and this will be compared to the final histopat
Sponsors
Basavatarakam Indo American Cancer Hospital Research Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients willing to provide informed consent 2. Patients with newly diagnosed non metastatic breast cancer who have no clinically or radiologically demonstrable disease following neoadjuvant chemotherapy as seen on a mammogram and ultrasound of the breast.
Exclusion criteria
Exclusion criteria: 1. Patients with prior history of any malignancy 2. Patients with excision biopsy of the breast primary 3. Patients undergoing upfront surgery 4. Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| False negative rate of multiple core biopsies in predicting pathological complete responseTimepoint: 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Accuracy, positive and negative predictive value of multiple core biopsies in predicting pathological complete responseTimepoint: 18 months;Exploratory analysis between the multiple core biopsies,pathological complete response in the breast and pathological complete response in the axillaTimepoint: 18 months;Planned subgroup analysis for the false negative rate in triple negative and HER2 positive breast cancersTimepoint: 18 months | — |
Countries
India
Contacts
Public ContactDr Nisha Hariharan
Basavatarakam Indo American Cancer Hospital and Research Institute
Outcome results
None listed