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A clinical trial to compare the effects and dose requirement of the drug - morphine when given through a catheter placed at a higher point in the vertebral column or at a lower point in the vertebral column in patients undergoing upper abdominal surgeries.

Comparison of morphine requirement in thoracic and lumbar epidural in patients undergoing upper abdominal surgeries using patient controlled epidural analgesia – A randomized clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/01/011068
Enrollment
60
Registered
2018-01-01
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Adult patients aged between 18-60 years scheduled for elective upper abdominal surgery under general anesthesia belonging to American Society of Anaesthesiologists (ASA) physical status I and II.

Interventions

Intervention1: Thoracic epidural group: Estimation of epidural morphine requirement in patients undergoing upper abdominal surgeries using patient controlled epidural analgesia with epidural catheter

Sponsors

Jawaharlal institute of postgraduate medical education and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients scheduled for elective upper abdominal surgery under general anesthesia 2) American Society of Anesthesiologists(ASA) physical status I and II

Exclusion criteria

Exclusion criteria: 1) Patient refusal. 2) Known case of Coagulopathy 3) Spine deformities 4) Pregnancy 5) Allergy to morphine or lignocaine 6) History of allergic disorders 7) High risk to develop post-operative nausea and vomiting (Apfel score >3) 8) Inability to comprehend pain score or understand use of PCEA 9) Expected prolonged post-operative ventilation

Design outcomes

Primary

MeasureTime frame
To assess and compare the 24 hour Morphine requirement between Thoracic and Lumbar epidural routes to provide adequate post-operative analgesia in patients undergoing upper abdominal surgeries using PCEA.Timepoint: Amount of Epidural Morphine (in milligrams) required by the patient for adequate pain relief in the post operative period. It is estimated at the end of 24 hours in post operative period.—

Secondary

MeasureTime frame
To assess and compare the incidence of Morphine related side effects which includes pruritus, nausea, vomiting, respiratory depression between the two groupsTimepoint: The number of Morphine related side effects in assessed for a period of 24 hours in post operative period.;To assess and compare the quality of post-operative analgesia of Morphine between the two groups using visual analog scale (VAS) score: at rest (VAS-R) and after coughing (VAS-C)Timepoint: Visual Analog Score (VAS) (Score 1 - 10) is assessed every 1 hour for the first 6 hours in the post operative period and then at 12 hours and 24 hours in the post operative period.—

Countries

India

Contacts

Public ContactDr Rajasekar R

Jawaharlal Institute of Postgraduate Medical Education and Research

drmohanvk@yahoo.co.in9841546265

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026