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Prevention of contrast induced acute kidney injury by Remote ischemic preconditioning

Remote ischemic preconditioning for prevention of contrast medium-induced nephropathy in patients of CKD stage 3 & 4 undergoing coronary angiography

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/12/011049
Enrollment
60
Registered
2017-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients of Chronic kidney disease stage 3 & 4 undergoing coronary angiography for evaluation of stable angina pectoris

Interventions

Intervention1: intervention group: 1. remote Ischemic Preconditioning will be accomplished by performing 4 cycles of alternating 5-minute inflation and 5-minute deflation of a standard upper-arm blood
3. Withdrawal of nephrotoxic drugs (eg, aminoglycosides, nonsteroidal anti-inflammatory drugs, calcineurin inhibitors, metformin, and others). 4. Limitation of contrast medium application to 5 x body
osmolarity 0.64 Osm/kg H2O at 37°C), a nonionic low-osmolar contrast medium, would be used. 3.In accordance with internal departmental guidelines, all patients will receive standard care for patient

Sponsors

IPGMER KOLKATA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Eligible patients will be >=18 years of age, presenting with stable angina pectoris, and was admitted to the Department of Cardiology of the SSKM HOSPITAL of IPGME&R for elective Coronary Angiography. 2. The renal function test of the patients who reveal impaired renal function with elevated serum creatinine of >1.4 mg/dL or reduced eGFR 186 x (serum creatinine [mg/L])-1.154 x (age [years])-0.203 x (0.742 if female) x (1.210 if of African descent).

Exclusion criteria

Exclusion criteria: 1.The patient who has end-stage renal failure with the need for haemodialysis or reduced eGFR 2.Patients unwilling for procedure. 3.Pregnant females will be excluded for study

Design outcomes

Primary

MeasureTime frame
incidence of Contrast medium Induced Acute Kidney InjuryTimepoint: within a period of 48 hours after contrast medium administration.—

Secondary

MeasureTime frame
1.Secondary outcomes will be the maximum elevation of serum creatinine in a 48-hour period after contrast medium exposure. 2.The composite cardiovascular end point included death, rehospitalization, or hemodialysis during 6-week follow-up. Timepoint: within 48-hour period after contrast medium exposure and during 6-week follow-up.—

Countries

India

Contacts

Public ContactRaju Kumar Sahu

IPGMER

sendebabrata58@gmail.com9883007370

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026