Effect on oxidative stress and inflammation in Chronic Kidney Disease patients â?? A comparative study between two intravenous iron preparations

Effect on oxidative stress and inflammation in Chronic Kidney Disease patients â?? A comparative study between Iron sucrose and Ferric carboxymaltose

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Observational

Source

CTRI

Registry ID

CTRI/2017/12/010990

Enrollment

120

Registered

2017-12-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic kidney disease stage 4 and 5

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Stable CKD stage 4 and 5 pre HD patients with iron deficiency anemia as per KDIGO guidelines {iron saturation (serum iron/total iron binding capacity) less than 20% or serum ferritin less than 200ng/L

Exclusion criteria

Exclusion criteria: Patients with 1. Active / recent infection in the last two weeks 2. Oral or IV iron, blood transfusions received in the last two weeks. 3. Malignancy, liver disease, pregnancy, hypersensitivity to IV iron

Design outcomes

Primary

Measure	Time frame
Outcome measures: The outcome studied were the effect of iron therapy on change in CRP and Malondialdehyde between the groups.Timepoint: The levels of CRP and Malondialdehyde will be done 1 hour prior to dose and 72 hour after the treatment	—

Secondary

Measure	Time frame
The secondary outcomes studied were adverse events and response to therapy. Timepoint: at the end of 30 days	—

Countries

India

Contacts

Public ContactShankar Prasad Nagaraju

Kasturba Medical college, Manipal University

shankarmmcmed@yahoo.com9739905443

Outcome results