A clinical study to see the effects of two different drugs, in patients undergoing laser for angle closure glaucoma

A Prospective, Randomized Study to Compare the Safety and Efficacy of Topical 0.1% Nepafenac Eye Drops with Topical 1% Prednisolone Acetate Eye Drops in Primary Angle Closure Suspects Undergoing YAG Peripheral Iridotomy.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/12/010922

Enrollment

152

Registered

2017-12-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H408- Other glaucoma Health Condition 2: null- Primary angle closure suspects undergoing laser peripheral iridotomy

Interventions

Intervention1: Prednisolone acetate 1% topical eye drops, one drop 4 times/day for 7 days then 2 times/day for additional 7 days. Total duration 14 days.: Steroidal anti-inflammatory drug Control Int

Eligibility

Inclusion criteria

Inclusion criteria: 1. Best corrected visual acuity 6/9 or more 2. Primary angle closure suspects

Exclusion criteria

Exclusion criteria: 1. Corneal pathology 2. Significant cataract (obscuring undilated fundus view) 3. Intra ocular pressure more than 21 mm of Hg 4. Peripheral anterior synechiae 5. Glaucomatous optic neuropathy 6. History of use of topical or systemic steroids one month prior to laser iridotomy 7. History of use of topical or systemic NSAIDS one month prior to laser iridotomy

Design outcomes

Primary

Measure	Time frame
To compare level of anterior chamber inflammation control between 0.1% Nepafenac and 1% Prednisolone acetate groups.Timepoint: 2 weeks and 4 weeks post laser	—

Secondary

Measure	Time frame
To compare the changes in IOP between 0.1% Nepafenac and 1% Prednisolone acetate groups.Timepoint: 2 weeks and 4 weeks post laser	—

Countries

India

Contacts

Public ContactDr Keerthi Gayam

Aravind eye hospital

venkatesh@pondy.aravind.org

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026