Health Condition 1: K85- Acute pancreatitis Health Condition 2: null- Patients with predicted severe acute pancreatitis within 3 days of onset of illness
Conditions
Interventions
Intervention1: Intravascular plasma volume guided fluid therapy group: Intravascular fluid will be infused based on calculated fluid deficit. We will calculate the fluid requirement plus maintenance f
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. All consecutive patients with predicted severe acute pancreatitis diagnosed as per revised Atlanta criteria will be included in the study. 2. Hospitalisation within 72 hours of onset of acute pancreatitis
Exclusion criteria
Exclusion criteria: 1. Age 60 years 2. Patients with Grade 3 / Grade 4 organ failure (as defined by modified marshall classification at enrolment). 3. Patients with underlying co-morbid cardiac, renal, hepatic disease or malignancy. 4. Patients admitted after 72 hours of onset of acute pancreatitis. 5. Pregnancy 6. Refusal to provide consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome meeting (2 out of the 4 ) adequate perfusion goals : SBP more than 100 mm Hg or 40 mm rise from baseline Pulse less than 100 beats per min Urine output more than 0.5 ml per kg per hr Lactate to normal values within 24 hours of resuscitation. Co-primary outcome will be measured by improvement in SIRS. Secondary outcome will be measured by improvement of organ failure at 72 hours and after 7 days of onset of AP and the difference in the adverse events between the groups Timepoint: from illness onset till 72 hours and 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome will be measured by improvement of organ failure at 72 hours and after 7 days of onset of AP and the difference in the adverse events between the groupsTimepoint: From illness onset till 72 hours and 7 days | — |
Countries
India
Contacts
Public ContactDr Rahul sethia
Aiims
Outcome results
None listed