Health Condition 1: null- patients undergoing invasive liver related procedures in patients with chronic liver disease.
Conditions
Interventions
Intervention1: Standard Therapy arm.: Conventional methods (prothrombin time, platelet count) guided transfusion of blood products.
Control Intervention1: TEG Therapy arm: Thromboelastography guided t
Sponsors
Department of Gastroenterology AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient undergoing invasive liver related procedures (eg, percutaneous liver biopsy, transjugular liver biopsy, transarterial chemoembolization, hepatic vein angioplasty/stenting, transjugular intrahepatic portosystemic shunt (TIPS) 2. Age between 18-65 years 3. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Patients with malignancy/disseminated intravascular coagulation (DIC)/known coagulopathic disorder (haemophilia) apart from cirrhosis. 2. History of intake of platelets inhibitors (eg, aspirin, clopidogrel) and drugs affecting coagulation cascade (eg, vitamin K anatagonists) within past 7 days 3. Pregnant women and those on oral contraceptives 4. Patients with chronic renal failure 5. History of underlying hypercoagulable/ hypocoagulable states eg. paroxysmal nocturnal hemoglobunuria(PNH), polycythemiavera etc 6. Patients receiving blood products (fresh frozen plasma and platelet prior to thromboelastography) 7. Patients with shock 8. Sepsis 9. Not willing to provide consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the requirement of blood products between the two groups (Standard transfusion group vs Thrombolastography guided group)Timepoint: 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding related complications within first days of the procedure.Timepoint: 5 days after procedure. | — |
Countries
India
Contacts
Public ContactDr Shalimar
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed