A study to determine if a new therapy(High Volume Plasma Exchange) can help in recovery of Acute on chronic Liver failure.

Role of High Volume Plasma Exchange in Acute on chronic Liver failure: A Pilot Randomized Control Trial. - HVPE-ACLF

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/12/010820

Enrollment

Registered

2017-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Acute on Chronic Liver Failure

Interventions

Intervention1: High Volume Plasma Exchange plus Standard therapy: Removal of 15% of ideal body weight equivalent of plasma and replacement with transfusion of fresh frozen plasma. In addition standa

Eligibility

Inclusion criteria

Inclusion criteria: 1. Written informed consent. 2. > 18 years of age. 3. ACLF grade 1 or 2.

Exclusion criteria

Exclusion criteria: 1. ACLF grade 3 2. Systolic blood pressure 3. Lack of informed consent 4. Coexisting severe illness eg. coronary artery disease, malignancy etc 5. Post Liver Transplant patients 5. Pregnancy 6. Active infection- bacterial or fungal. 7. Hepatocellular carcinoma

Design outcomes

Primary

Measure	Time frame
To study the effect of high volume plasma (HVP) exchange on 28 day mortality in patients with alcohol-related ACLF.Timepoint: 28 days	—

Secondary

Measure	Time frame
To study the effect of HVP on CLIF-C ACLF score, APACHE II and SIRS. To study the effect of HVP on resolution of organ failures in ACLF. To study the effect of high volume plasma exchange on cytokine profile in ACLF. To study the incidence of infections and other complications in ACLF patients undergoing high volume plasma exchange Timepoint: 1 month 1 month 1 month 1 month	—

Countries

India

Contacts

Public ContactDr Shalimar

All India Institute of Medical Sciences

drshalimar@yahoo.com9868397211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026