Health Condition 1: null- Stage III or IV laryngeal or hypopharyngeal SCC
Conditions
Interventions
None listed
Sponsors
Kasturba Hospital Manipal
Eligibility
Inclusion criteria
Inclusion criteria: Patients with hypopharyngeal and laryngeal SCC (except T1N0 and T2N0 Glottic cancers), Stages III â?? IV (AJCC) treated with definitive VMAT
Exclusion criteria
Exclusion criteria: 1. Patients with laryngeal and hypopharyngeal tumors with histology other than SCC 2. Patients with Stage I/II tumors 3. Patients with distant metastasis 4. Patients undergoing upfront laryngectomy 5. Initial Karnofsky Performance Status (KPS) less than 60%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To report the loco-regional control (LRC) rate of locally advanced laryngeal and hypopharyngeal cancers treated using definitive VMAT (+ chemotherapy)Timepoint: Assessment at 3 monthly intervals | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To report the median laryngectomy free survival on follow-up 2. To report the median distant metastasis free survival on follow-up 3. To report the incidence rate of residual disease at the end of treatment. 4. To report the median overall survival on serial follow-up 5. To report the incidence of acute toxicity with VMAT based IMRT 6. To report the incidence of late toxicity with VMAT based IMRTTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactFathima Almas
KMC Manipal
Outcome results
None listed