Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecified Health Condition 2: K318- Other specified diseases of stomach and duodenum Health Condition 3: null- Patients with 18-70 yrs of age, ASA grade I and II, undergoing elective major abdominal surgery will be enrolled.
Conditions
Interventions
Intervention1: low dose intravenous ketamine, lumbar epidural analgesia, thoracic epidural analgesia.: low dose intravenous ketamine to lumbar epidural analgesia versus thoracic epidural analgesia in
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: patients with 18-70 yrs of age, ASA grade I and II, undergoing elective major abdominal surgery will be enrolled after taking informed written consent.
Exclusion criteria
Exclusion criteria: Patients refusing to participate in the study, emergency surgeries, laparoscopic surgeries, re-exploration surgeries, allergy to local anaesthetic drugs, coagulopathies, patients on anticoagulants, more than three attempts for epidural placement and patients who cannot be extubated within 2 hours of surgery will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of addition of low dose intravenous ketamine to lumbar epidural analgesia versus thoracic epidural analgesia in reducing postoperative Visual analog scale (VAS) score in patients undergoing major abdominal surgeries.Timepoint: In the post-operative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| To establish their effect on inflammatory markers and analgesic consumption.Timepoint: . Three samples for inflammatory markers will be collected at pre-induction, at the end of surgery (at the time of closure) and 24 hours after surgery to measure IL-6, IL-10 and TNF alpha, C reactive protein (CRP) and Serum cortisol. | — |
Countries
India
Contacts
Public ContactDr Neha Singh
All India Institute of Medical Sciences, Bhubaneswar
Outcome results
None listed