Health Condition 1: null- All Adult Intensive care unit patients were included
Conditions
Interventions
None listed
Sponsors
Dr Kiran Kumar Gudivada
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than 18 years (No upper limit of age, as age is not a contraindication for administration of drug cefoperazone) 2. Those who received cefoperazone for more than 3 days
Exclusion criteria
Exclusion criteria: 1. Those patients on warfarin therapy 2. Pre existing elevated PT/INR and bleeding manifestations 3. Received vitamin K one day prior to initiation of cefoperazone All other patients with increased hepatic enzymes, sepsis with multi-organ failure, renal failure, immunosuppressed with neutropenia were not excluded unless they have a preexisting derangement in INR and/or clinical bleeding manifestation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure the incidence of cefoperazone induced elevation in INR more than 1.5Timepoint: Within Six days of initiation of cefoperazone | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Evaluate risk factors for cefoperazone associated coagulopathy 2. Rescue treatment offered to patients such as therapeutic vitamin K administration and/or blood product transfusions 3. Length of ICU and Hospital stay 4. Mortality in ICUTimepoint: Within Six days of initiation of cefoperazone | — |
Countries
India
Contacts
Public ContactDr Kiran Kumar Gudivada
St. Johns Medical College and Hospital
Outcome results
None listed