Health Condition 1: G938- Other specified disorders of brain Health Condition 2: null- WNT subgroup Medulloblastoma
Conditions
Interventions
Intervention1: Radiation Therapy: All the patients will be treated using any contemporary Linear accelerator machine capable of delivering rotational volumetric arc therapy (VMAT) based Radiotherapy w
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Newly diagnosed WNT pathway medulloblastoma Post surgery residual disease less than 1.5 cm2 on post operative MRI brain. No evidence of metastatic disease in the brain, spine or cerebral spinal fluid (CSF) assessed by MRI of the brain and spine and a lumbar puncture for CSF cytology.
Exclusion criteria
Exclusion criteria: Age Less than 3 and more than 16 years. Molecular subgroup other than WNT pathway. Post surgery residual disease more than 1.5cm2 on post-operative imaging Evidence of any metastatic disease in the brain, spine or cerebral spinal fluid (CSF). Previous history of radiotherapy or chemotherapy prior to study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse free survivalTimepoint: Relapse free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate neurocognitive outcomes and endocrine function prospectively using this approach.Timepoint: To evaluate neurocognitive outcomes and endocrine function prospectively using this approach. | — |
Countries
India
Contacts
Public ContactDr Tejpal Gupta
Tata Memorial Hospital
Outcome results
None listed