Evaluation and comparison of the efficacy of locally delivered ocimum sanctum gel and 8-Hydroxydeoxyguanosine levels in gingival crevicular fluid in subjects with chronic periodontitis before and after scaling and root planning therapy.

Evaluation and comparison of the efficacy of locally delivered ocimum sanctum gel and 8-Hydroxydeoxyguanosine levels in gingival crevicular fluid in smoker and non smoker with chronic periodontitis patients before and after phase I therapy

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/12/010748

Enrollment

Registered

2017-12-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Healthy and Smoker patients with Chronic periodontitis and Non Smoker patients with Chronic periodontitis

Interventions

Intervention1: Scaling and root planing and local drug delivery.: Topical Application of 10 % Tulsi gel in group I and group II patient of one side on baseline and plane scaling and root planing on o

Eligibility

Inclusion criteria

Inclusion criteria: Group I Periodontally healthy subjects Gingival index equel to 0 Periodontal pocket depth greater than equal to 3 mm and clinical attachment level equal to 0 Group II SmokerSubjects with mild to moderate Chronic periodontitis Gingival Index greater than or equal to 1mm Periodontal pocket depth than or equal to 5mm and Clinical attachment levelgreater than or equal to 3mm and H/O smoking at least 7-8 cigarettes per day for last 3 year GroupIII Non smoker subjects with mild to moderate Chronic periodontitis gingival index 1pocket depth of greater than or equal to 5mm and clinical attachment level greater than or equal to 3mm

Exclusion criteria

Exclusion criteria: 1 Medically compromised patients 2 Patient with systemic disease 3 Pregnant and lactating mother 4 Patient received periodontal therapy antibiotics or antioxidant therapy within 6 months 5 Patient with acute illness

Design outcomes

Primary

Measure	Time frame
To cheak Improvement in periodontal status and reduction of periodontal pocket depth and gain clinical attachment level in smoker and non smoker periodontitis patientTimepoint: 2 year	—

Secondary

Measure	Time frame
To compare the efficacy of locally delivered ocimum sanctum gel and 8-OHdG level in gingival crevicular fluid in smokers and non smokers with chronic periodontitis patientsTimepoint: 2 year	—

Countries

India

Contacts

Public ContactAbhay Kolte

VSPM Dental College

drsurekhar@gmail.com9011071477

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026