Health Condition 1: null- Squamous cell carcinoma of the Head and Neck
Conditions
Interventions
Intervention1: Adaptive Radiotherapy: Adaptive radiotherapy is done for the patient if the dose to the parotids are increased during radiation as per the protocol specifications
Control Intervention1:
Sponsors
Tata Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pathologically proven squamous cell carcinomas of head and neck including oropharynx, hypopharynx, larynx and nasopharynx. History and physical examination prior to the start of the treatment. For those undergoing radical treatment physical examination should have been done as recent as two weeks prior to the start of the treatment. CT of the Head and Neck region, CT Chest to be done as part of the staging protocol. 2. Age between 18 â?? 70 years 3. ECOG 0 or 1 4. Undergoing radical or adjuvant radiation/chemoradiation and requires bilateral neck irradiation. 5. One or both parotids are intended to receive at least a dose between 25 â?? 30 Gy in the initial plan. No exceptions to the eligibility criteria are permitted.
Exclusion criteria
Exclusion criteria: 1. Prior surgery of the parotid glands 2. Prior radiation therapy to the head and neck region. 3. Prior cytotoxic chemotherapy 4. Patients having xerostomia as per the pre radiotherapy evaluation 5. Both the parotids are receiving more than 50 Gy in the initial plan. 6. Patients with distant metastases. 7. Unlikely to be on follow up with us after completion of radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To calculate the person hours for Adaptive Radiotherapy for those undergoing the same on Helical Tomotherapy and Rapidarc compare it with the person hours calculated for standard IMRT techniquesTimepoint: Weekly assessment during treatment QOL assessment at pre-treatment, 3 months post-treatment and 9-months post-treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessing the anxiety and the depression of the patients using Hospital Anxiety and Depression Scale (HADS).Timepoint: Baseline, at 3 months and at 9 months of follow up;Quality of Life assessment for all patients undergoing conventional Intensity Modulated radiation therapy or adaptive Radiotherapy using EORTC QLQ C30 and QLQ HN 35. Timepoint: Baseline, at 3 months and at 9 months of follow up;Xerostomia assessment of all patients using xerostomia-related quality of life scale (XeQoLS). Timepoint: Baseline, at 3 months and at 9 months of follow up | — |
Countries
India
Contacts
Public ContactMoses Arunsingh
Tata Medical centre
Outcome results
None listed