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A clinical trial to compare the efficacy of thorough cleaning with placement of PepGen P-15 a bone graft and thorough cleaning alone in treatment of periodontitis patients, clinically and radiographically.

A Comparative Evaluation of the Effectiveness of Anorganic Bone Matrix/Cell Binding Peptide PepGen P-15 with Open Flap Debridement (OFD) in the Treatment of Human Infrabony Defects- A Clinical and Radiographic Study - nil

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010669
Enrollment
20
Registered
2017-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic Periodontitis Patients

Interventions

Intervention1: The trial is an Interventional trial in the treatment of chronic periodontitis comparing two different treatment modalities one involving the placement of Anorganic Bone Matrix/Cell Bin

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Presence of at least 2 radiographically detectable interproximal osseous defects with a probing depth >=5mm & clinical attachment loss >= 5mm following initial therapy. 2. The depth of the intraosseous component of the defect estimated as >=3mm by clinical and radiographic means.

Exclusion criteria

Exclusion criteria: 1. Subjects with history of systemic diseases, allergies or drug usage. 2. Subjects who have undergone periodontal treatment in previous 6 months 3. Teeth exceeding class II mobility.

Design outcomes

Primary

MeasureTime frame
Primary outcomes: Improvement in Periodontal Status i.e. reduction in Probing Pocket Depth, gain in Clinical Attachment Level, Bone Fill in Periodontal Infrabony Defect (seen radiographically)Timepoint: outcome will be assessed at 3 months and 6 months.

Secondary

MeasureTime frame
Reduction in Plaque scores and Gingival Bleeding scores representing improvement in Gingival (soft tissue) statusTimepoint: At 6 months

Countries

India

Contacts

Public ContactDr. Abhay P. Kolte

V.S.P.M Dental College & Research Centre

drabhaypkolte@gmail.com09011071467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026