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Comparison of xylometazoline(vasoconstrictor) nasal drops and epinephrine merocel nasal pack in reducing bleeding during nasal intubation

Effect of xylometazoline nasal drops in reducing epistaxis during nasotracheal intubation versus epinephrine merocel nasal pack

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010658
Enrollment
110
Registered
2017-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Epistaxis during nasotracheal intubation

Interventions

Intervention1: xylometazoline: 0.6ml/3 drops of 0.1% xylometazoline nasal drops will be instilled in both the nostrils of the patient. Anaesthesiologist ,performing the intubation will comment on the

Sponsors

Postgraduate institute of medical education and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and ASA 2 patients with normal coagulation profile requiring nasal intubation for any surgery of duration upto 4hours.

Exclusion criteria

Exclusion criteria: 1.H/O cough and cold in past two weeks 2.Patients taking any oral decongestants, nonsteroidal inflammatory drugs(NSAIDS) or anti histamines 3.H/O nasal deformity or nasal trauma 4.H/O recurrent epistaxis, known allergy to used drugs 5.Patients with dearanged liver function profile 6.Pregnancy 7.Uncontrolled hypertension

Design outcomes

Primary

MeasureTime frame
1.To see the presence and scale of bleeding due to NTI using xylometazoline nasal drops versus epinephrine merocel nasal pack. Timepoint: 30 minutes

Secondary

MeasureTime frame
1.To see the presence of bleeding during extubation. 2.To assess the navigability through the nasal passage 3.To assess post operative patient comfort level in terms of difficulty in nasal breathing or nasal pain,any nasal trauma or persistent nasal bleeding. Timepoint: 1 hour

Countries

India

Contacts

Public ContactSonam Patel

Postgraduate institute of medical education and research

amarjyoti28@rediffmail.com9990238972

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026