Health Condition 1: null- Infant of diabetic mother more than 35 weeks of gestational age and more than 2 kg.
Conditions
Interventions
Intervention1: 40% dextrose gel: 1.Strict thermoregulation in delivery room (NRP recommendation)
2.Apply oral dextrose gel 200mg/kg over buccal mucosa
3.Start Direct breast feeding (within 30 mins)
4.
Sponsors
Christian Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Infant of diabetic mother more than 35 weeks of gestational age and more than 2 kg.
Exclusion criteria
Exclusion criteria: 1. Requiring admission before randomization (preterm neonates less the 35 weeks of gestational age, birth weight less than 2000 grams, respiratory distress, major lethal congenital malformation, antenatal ultrasound findings with absent/reversal of end diastolic mesenteric flow, Rh negative mother with DCT positive baby and indication suggested by consultants). 2. No consent 3. Major congenital malformation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoglycemiaTimepoint: in the first 24 hours after birth | — |
Secondary
| Measure | Time frame |
|---|---|
| Number Needed to TreatTimepoint: till 24 hours of life;Onset of action and duration of action of oral dextrose gelTimepoint: till 24 hours of life;Compliance of careTimepoint: till 24 hours of life;Duration of hospital stayTimepoint: within 28 days of life;Incidence of feed intoleranceTimepoint: till 24 hours of life;Incidence of hyperglycemiaTimepoint: till 24 hours of life;Incidence of late hypoglycemiaTimepoint: till 24 hours of life;Incidence of Necrotizing EnterocolitisTimepoint: till 24 hours of life;Incidence of rebound hypoglycemiaTimepoint: till 24 hours of life;Incidence of sepsis without antenatal risk of sepsisTimepoint: till discharge;Maternal satisfactionTimepoint: till discharge;Maximum requirement of Glucose Infusion RateTimepoint: till 24 hours of life;Formulation of scoring system to predict the responder and non-responder to oral dextrose gel based on following risk factors: Type of maternal diabetes Uncontrolled maternal diabetes Placentomegaly cord blood glucose cord blood C peptide level rate of fall of blood glucose at one and half an hour SGA LGA macrosomia IUGR prematurity low birth weight PIH maternal use of beta blocker and dextrose containing IV fluids during labor cold stress hypothermiaTimepoint: one and half an hour of life;Rate of exclusive breast feeding till discharge determined by parental QuestionnaireTimepoint: till discharge;Rate of exclusive breast feeding up to 6 months of ageTimepoint: 6 months of life;Rate of rise of glucose due to oral dextrose gelTimepoint: till 24 hours of life;Reduction in admission rate due to hypoglycemia Timepoint: in the first 24 hours after birth | — |
Countries
India
Contacts
Public ContactThanigainathan
Christian Medical College
Outcome results
None listed