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A Clinical trial to study the effects of three drugs- Ondansetron, Lidocaine and Dexamethasone in relieving pain caused by injection of Propofol during induction of sleep during general anaesthesia.

Prevention of Propofol injection pain:A comparison between Ondansetron,Dexamethasone and Lidocaine. - PLOD

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/11/010628
Enrollment
150
Registered
2017-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- COMING FOR ELECTIVE SURGERY UNDER GENERAL ANESTHESIA WITH NO HYPERTENSION/DIABETES MELLITES

Interventions

Intervention1: injection ondansetron 4mg, injection Lidocaine 40mg or Injection Dexamethasone 6mg.: pretreatment with injection ondansetron 4mg, injection Lidocaine 40mg or Injection Dexamethasone 6mg

Sponsors

Department of Anesthesiology St johns medical college hospital Bangalore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients in the age group 18-59 yrs 2. American society of anaesthesiology (ASA) physical status I and II. 3. All general surgical procedures .

Exclusion criteria

Exclusion criteria: 1. Patients with allergy to propofol, lignocaine. 2. Patients with anticipated difficult airway 3. Patients with cardiac conduction defects, congenital heart diseases 4. Haemodynamic instability 5. Patients with chronic pain syndromes.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of pre-treatment with lidocaine, ondansetron or dexamethasone in reducing the pain of propofol injection in adult patients scheduled for surgical procedures under general anaesthesia. Timepoint: assessment of pain scoring 15 seconds after administering propofol

Secondary

MeasureTime frame
To assess any reaction to the drug at injection site.Timepoint: at the end of general surgical procedure approximately 60-90 minutes.

Countries

India

Contacts

Public ContactDr Arpana Kedlaya

ST JOHNS MEDICAL COLLEGE HOSPITAL.

drarpanak@hotmail.com9945346123

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026